abstract：:31P Magnetic Resonance-Spectroscopy was performed at the site of tender points in the trapezius muscle of patients with primary fibromyalgia syndrome. Earlier, in vitro studies have reported changes in the high energy phosphate-metabolism in biopsies taken from tender points of fibromyalgia patients. The observed alte...

journal_title：Rheumatology international

authors： de Blécourt AC,Wolf RF,van Rijswijk MH,Kamman RL,Knipping AA,Mooyaart EL

更新日期：1991-01-01 00:00:00

abstract：:The induction of experimental arthritis in rhesus monkeys was studied by intradermal immunization of bovine type II collagen and antigens derived from Mycobacterium tuberculosis, Streptococcus pyogenes, and Eubacterium aerofaciens. The tested bacterial antigens proved to be not arthrogenic. Bovine type II collagen ind...

journal_title：Rheumatology international

authors： Bakker NP,van Erck MG,Zurcher C,Faaber P,Lemmens A,Hazenberg M,Bontrop RE,Jonker M

更新日期：1990-01-01 00:00:00

abstract：:Monocyte interleukin-1 (IL-1) production in vitro was studied in 49 patients with rheumatoid arthritis (RA) and 31 controls. Twenty-six of the RA patients were studied prospectively for up to 12 months after beginning chrysotherapy. About half of the patients (group 1) exhibited pretreatment levels of monocyte IL-1 se...

journal_title：Rheumatology international

authors： Danis VA,Kulesz AJ,Kelly DE,Nelson DS,Brooks PM

更新日期：1990-01-01 00:00:00

abstract：:Low molecular weight IgM (LMW IgM) is the monomeric subunit of the naturally occurring pentameric IgM. It is not seen in health but has been previously observed in systemic lupus erythematosus (SLE) particularly in those patients with active disease and may reflect an adverse prognostic finding. We have therefore stud...

journal_title：Rheumatology international

authors： Roberts-Thomson PJ,Shepherd K,Bradley J,Boey ML

更新日期：1990-01-01 00:00:00

abstract：:Measurement of the complement activation products C1s:C1-inh, C3bP and C5b-9 by ELISA in plasma samples from normals, rheumatoid arthritis (RA) and systemic lupus erythematosis (SLE) patients showed significantly elevated levels in the two patient groups (P less than 0.0001 for C1s:C1-inh, C3bP and C5b-9) compared to ...

journal_title：Rheumatology international

authors： Auda G,Holme ER,Davidson JE,Zoma A,Veitch J,Whaley K

更新日期：1990-01-01 00:00:00

abstract：:Protein synthesis in all cells is readily interrupted by environmental stresses such as hyperthermia. However, stressed cells also have mechanisms which, even under conditions where normal protein synthesis is completely inhibited, allow them to synthesise a group of highly conserved proteins--the so-called heat shock...

journal_title：Rheumatology international

authors： Hurst NP

更新日期：1990-01-01 00:00:00

abstract：:Some nonsteroidal anti-inflammatory drugs (NSAIDs) used in the treatment of osteoarthritis (OA) may damage articular cartilage. This damage may be caused by suppression of proteoglycan synthesis or by altered collagen synthesis in the presence of prostaglandin E2 (PGE2) induced by interleukin-1 (IL-1). The clinical an...

journal_title：Rheumatology international

authors： Bacon PA

更新日期：1990-01-01 00:00:00

abstract：:A total of 95 patients suffering from active rheumatoid arthritis were included in this double-blind, placebo-controlled study of the immunomodulator OM-8980. Treatment was one capsule daily of OM-8980 or placebo for 6 months. A significant improvement was observed in the OM-8980 group in comparison with the placebo g...

journal_title：Rheumatology international

authors： Hauzeur JP,Appelboom T

更新日期：1989-01-01 00:00:00

abstract：:The occurrence of MHC class I antigens and microbial antigens derived from the triggering infection of the diseased joints in reactive arthritis (ReA) seems to set the stage for local immune activation. In this report activated lymphocytes are demonstrated by using an avidin-biotin-peroxidase complex (ABC) method comb...

journal_title：Rheumatology international

authors： Nordström DC

更新日期：1989-01-01 00:00:00

abstract：:We measured alpha 2-plasmin inhibitor-plasmin complexes (PI-PC) in plasma of patients with systemic lupus erythematosus (SLE) to examine the plasminogen activation in SLE. The plasma PI-PC level in 23 patients with SLE was significantly higher than that in 18 normal subjects (P less than 0.001) and the SLE patients wi...

journal_title：Rheumatology international

authors： Negoro N,Kanayama Y,Takeda T,Fujisawa M,Okamura M,Inoue T

更新日期：1989-01-01 00:00:00

abstract：:The presence of specific anti-Proteus antibodies in active, rheumatoid arthritis (RA) patients, has been demonstrated by four different techniques: indirect bacterial agglutination, ELISA, Western blotting and immunofluorescence. Furthermore, anti-HLA-DR4 tissue typing sera have been shown to bind to Proteus microorga...

journal_title：Rheumatology international

authors： Ebringer A,Khalafpour S,Wilson C

更新日期：1989-01-01 00:00:00

abstract：:An abnormal immune response towards the Epstein-Barr virus (EBV) has been documented in patients with rheumatoid arthritis (RA). To investigate whether these findings are due to the transformation event caused by EBV, RA blood mononuclear cells and monocyte-enriched preparations were incubated with two different EBV s...

journal_title：Rheumatology international

authors： Häupl T,Burmester GR,Hahn G,Feige U,Rordorf-Adam C,Kalden JR

更新日期：1989-01-01 00:00:00

abstract：:Arthrocutaneous disorders including Reiter's syndrome, psoriasiform rashes, and other forms of chronic arthritis and enthesopathy, such as psoriatic arthritis, occur with an increased prevalence in the setting of HIV infection. Herein we describe the spectrum and prevalence of musculoskeletal and allied skin disorders...

journal_title：Rheumatology international

authors： Brancato L,Itescu S,Skovron ML,Solomon G,Winchester R

更新日期：1989-01-01 00:00:00

abstract：:We investigated the effect of chrysotherapy on the Fc and complement receptor binding activity of peripheral blood (PB) monocytes and peritoneal (PE) macrophages isolated from normal rats and rats with adjuvant induced arthritis. The adjuvant induced severe disease in Dark Agouti (DA) rats and less marked disease in J...

journal_title：Rheumatology international

authors： Haynes DR,Garrett IR,Vernon-Roberts B

更新日期：1988-01-01 00:00:00

abstract：:Activated T lymphocytes (Ia+ T-cells) in peripheral blood are associated with immune stimulation. We found the percentages of these cells significantly increased in 95% of rheumatoid arthritis (RA) patients. Our studies showed no relation between the percentages of these cells in peripheral blood and concurrent erythr...

journal_title：Rheumatology international

authors： Bartfeld H,Dham C

更新日期：1988-01-01 00:00:00

abstract：:The ultrastructural localisation of class II and macrophage antigens has been sought in the intimal layer of the human synovium. The cells described as type A in early morphological studies are shown to express both class II antigens and two markers of the macrophage/monocyte lineage of cells, OKM1 and MAB 24. The mor...

journal_title：Rheumatology international

authors： Mapp PI,Revell PA

更新日期：1988-01-01 00:00:00

abstract：:A community-based cohort comprising 150 patients with recent-onset seropositive arthritis or seronegative oligoarthritis or polyarthritis was monitored for 8 years. Of the different rheumatoid factor (RF) tests, the initial positivity in the most sensitive assays (latex slide test and IgM-RF by enzyme immunoassay) was...

journal_title：Rheumatology international

authors： Tuomi T,Aho K,Palosuo T,Kaarela K,von Essen R,Isomäki H,Leirisalo-Repo M,Sarna S

更新日期：1988-01-01 00:00:00

abstract：:An immunoglobulin-independent deposition of the complement (C) components C4 and C3 occurs on rat kidney medullary structures, when sera of patients with various inflammatory diseases are studied by indirect immunofluorescence. The diagnostic value of this new test (C4-C3-IFT) for polymyalgia rheumatica (PMR) is stres...

journal_title：Rheumatology international

authors： Vaith P,Hänsch GM,Peter HH

更新日期：1988-01-01 00:00:00

abstract：:A simple technique for fine-needle aspiration biopsy from the synovial membrane of arthritis knee joints preceded by lavage of the joint cavity is described. The procedure was atraumatic, well accepted, and could be performed on outpatients. Cells originating from the synovial membrane were obtained in 12 of 17 knees ...

journal_title：Rheumatology international

authors： Geborek P,Sandberg M,Wollheim FA

更新日期：1988-01-01 00:00:00

abstract：:The mononuclear phagocyte infiltrate which occupies the gout tophus has been compared with that of the subcutaneous rheumatoid nodule. In the gout tophus, macrophage migration appears to be at a relatively low level and effectively terminates once these cells have been recruited into the corona. In the nodule the evid...

journal_title：Rheumatology international

authors： Palmer DG,Hogg N,Denholm I,Allen CA,Highton J,Hessian PA

更新日期：1987-01-01 00:00:00

abstract：:Synovial fluids of patients suffering from rheumatoid arthritis contain elevated levels of granulocyte (PMN) elastase in complex with alpha 1-proteinase inhibitor (alpha 1-PI), whereas free-elastase activity is usually not detectable. This absence of free enzymatic activity in joint effusions has cast some doubt on th...

journal_title：Rheumatology international

authors： Burkhardt H,Kasten M,Rauls S,Rehkopf E

更新日期：1987-01-01 00:00:00

abstract：:Plasma fibronectin (FN) was measured in 17 patients with essential mixed cryoglobulinaemia (EMC) and in 17 normal subjects by single radial immunodiffusion (RID) and enzyme-linked immunosorbent assay (ELISA). In 9 patients the presence of FN in the cryoprecipitates was also assessed by immunoblotting. In the EMC group...

journal_title：Rheumatology international

authors： Toschi V,Renoldi P,Motta A,Cimminiello C,Arpaia G,Fiorini GF

更新日期：1987-01-01 00:00:00

abstract：:A total of 300 consecutive patients referred to a tertiary-care center and fulfilling the American Rheumatism Association criteria for definite-classical rheumatoid arthritis, (with a mean disease-duration of 10.3 +/- 9 years) were studied by structured interview and medical record review. The type of onset (rapid or ...

journal_title：Rheumatology international

authors： Halla JT,Hardin JG,Fallahi S

更新日期：1987-01-01 00:00:00

abstract：:Using a sensitive and specific enzyme-linked immunosorbent assay (ELISA) assay we showed that the cryoglobulins of a patient with Lucio phenomenon contain phenolic glycolipid I antigen and a specific antibody. ...

journal_title：Rheumatology international

authors： Drosos AA,Brennan PJ,Elisaf MS,Stefanou SG,Papadimitriou CS,Moutsopoulos HM

更新日期：1986-01-01 00:00:00

abstract：:Neopterin levels of serum and fluid were determined in 30 patients with inflammatory synovial fluids and in 30 controls with joint effusions induced by trauma or osteoarthritis. Neopterin was significantly elevated in inflammatory fluids. There was no correlation with the acute phase reactants. Neopterin levels were s...

journal_title：Rheumatology international

authors： Maerker-Alzer G,Diemer O,Strümper R,Rohe M

更新日期：1986-01-01 00:00:00

abstract：:Proliferation of pannus tissue cells has been investigated under in vitro conditions after labeling of joint tissues with 3H-thymidine. It was demonstrated that there is only a minimal proliferation of chondrocytes as well as of pannus tissue cells. Slight increased proliferation was observed in granulation tissue poo...

journal_title：Rheumatology international

authors： Mohr W,Hummler N,Pelster B,Wessinghage D

更新日期：1986-01-01 00:00:00

abstract：:Seven females and one male with almost identical sclerotic and hyperostotic changes of the manubrium sterni are reported. The clinical course was prolonged and characterized by intermittent periods of exacerbation followed by improvement. Malignancies, bacterial inflammatory processes, and Paget disease, which were fi...

journal_title：Rheumatology international

authors： Jurik AG,Møller BN,Jensen MK,Jensen JT,Graudal H

更新日期：1986-01-01 00:00:00

abstract：:Clinically diagnosed cases with different grades of rheumatoid arthritis (RA) were studied for (a) cryoglobulin content (b) constituents of cryoglobulins, and (c) rheumatoid factor (RF) titers in sera and cryoglobulins. Of 60 patients, 28 (46.66%) had significantly high levels of cryoglobulins and were mainly distribu...

journal_title：Rheumatology international

authors： Chattopadhya D,Ravindran B,Prakash K

更新日期：1985-01-01 00:00:00

abstract：:One hundred and eighteen unrelated Greek patients with classic rheumatoid arthritis (RA) were tissue-typed for HLA-A, -B, -DR antigens and the frequency was compared to that of healthy controls. Greek RA patients regardless of sex, anatomical severity, seropositivity and age at disease onset are not associated with an...

journal_title：Rheumatology international

authors： Papasteriades CA,Kappou ID,Skopouli FN,Barla MN,Fostiropoulos GA,Moutsopoulos HM

更新日期：1985-01-01 00:00:00

abstract：:A 56-year-old woman presented with changes characteristic of the reflex sympathetic dystrophy syndrome (RSDS) but also frank synovitis of the left wrist, an elevated ESR and early damage of the left carpus on radiographs, suggesting septic arthritis. A dynamic scan showed changes characteristic of RSDS. A sample of sy...

journal_title：Rheumatology international

authors： Catoggio LJ,Fongi EG

更新日期：1985-01-01 00:00:00

abstract：:The atrioventricular conduction time (P-R interval) was determined in 189 women and 90 men with rheumatoid arthritis (RA). Only three women and one man were found to have pathological prolongation of the P-R interval. However, a significant prolongation of the P-R interval, within normal range, was seen in women with ...

journal_title：Rheumatology international

authors： Jurik AG,Møller P

更新日期：1985-01-01 00:00:00

abstract：:Immunofluorescence on polymorphonuclear cells (PMN) of patients with Felty syndrome (FS) revealed increased amounts of IgG, IgA, and IgM bound to the PMN surface compared with PMN of patients with rheumatoid arthritis alone. A positive correlation was found between the score for surface-bound immunoglobulins on FS-PMN...

journal_title：Rheumatology international

authors： Breedveld FC,Lafeber GJ,Doekes G,Claas FH,Cats A

更新日期：1985-01-01 00:00:00

abstract：:Intraperitoneal injection of pristane induced a clinical peripheral arthritis and/or tenosynovitis in 40% of 40 Balb/cJ/Ola mice. Hind paws were always affected first and fore paws were frequently involved. Involvement of knee joints was only apparent histologically. Some clinically unaffected animals and apparently u...

journal_title：Rheumatology international

authors： Hopkins SJ,Freemont AJ,Jayson MI

更新日期：1984-01-01 00:00:00

abstract：:A case of relapsing polychondritis with aortic arch aneurysm and aortic arch syndrome is described. The pattern of vascular involvement supports the inclusion of relapsing polychondritis within the spectrum of systemic vasculitides. ...

journal_title：Rheumatology international

authors： Giordano M,Valentini G,Sodano A

更新日期：1984-01-01 00:00:00

abstract：:The Sjögren's syndrome A antigen (SS-A) purified by affinity chromatography from human spleen was shown to contain a major polypeptide with a mol. wt. of 55 000 daltons confirmed as SS-A by its reactivity with different anti-SS-A sera on affinity columns, immunodiffusion and the Western blot. A similar reactive polype...

journal_title：Rheumatology international

authors： Smith PR,Venables PJ,Williams D,Maini RN

更新日期：1984-01-01 00:00:00

abstract：:In a prospective study 222 sera from 56 patients with systemic lupus erythematosus (SLE) were tested for antibodies to poly(A), poly dAT and histones using enzyme-linked immunosorbent assay (ELISA). Patients with active disease had significantly more often antibodies to poly(A), poly dAT and histones than patients wit...

journal_title：Rheumatology international

authors： Helve T,Gripenberg M,Kurki P,Teppo AM,Wegelius O

更新日期：1984-01-01 00:00:00

abstract：:In a study of synovial fluid from 110 patients with various forms of arthritis, platelets were identified in the synovial fluid of all the 50 rheumatoids, in 18 out of the 25 (72%) with osteoarthritis and in all 35 of those with other forms of inflammatory osteoarthrosis. Identification of platelets by light microscop...

journal_title：Rheumatology international

authors： Farr M,Wainwright A,Salmon M,Hollywell CA,Bacon PA

更新日期：1984-01-01 00:00:00

abstract：:We have examined the way in which products of cultured human blood mononuclear cells activate human articular chondrocytes. Conditioned medium from mononuclear cells enhanced the production of prostaglandin E by cultured human chondrocytes and also stimulated fibrinolytic activity in these cultures. These two effects ...

journal_title：Rheumatology international

authors： Meats JE,McGuire MK,Ebsworth NM,Englis DJ,Russell RG

更新日期：1984-01-01 00:00:00

abstract：:Chondrocyte structure and function under the influence of two gold-containing therapeutic agents, aurothioglucose and triethylphosphine gold, were studied in a monolayer culture system for cultivating lapine articular chondrocytes. The functional parameters investigated were chondrocyte proliferation and the incorpora...

journal_title：Rheumatology international

authors： Kirkpatrick CJ,Mohr W

更新日期：1983-01-01 00:00:00

abstract：:In a study of 199 patients with rheumatoid arthritis, 68% were found to have tried 'alternative treatments'. Some treatments (acupuncture and faith healing) gave subjective benefit in nearly half those who tried them and were considered to be better than others (such as copper bracelets). No adverse reactions were rep...

journal_title：Rheumatology international

authors： Struthers GR,Scott DL,Scott DG

更新日期：1983-01-01 00:00:00